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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
10/05/2011 |
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Data da última atualização: |
04/08/2011 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, NANCY E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. |
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Afiliação: |
JUAN PEDRO STEIBEL, Department of Animal Science, Michigan State University; RONALD O. BATES, Department of Animal Science, Michigan State University; GUILHERME J. M. ROSA, Department of Animal Sciences, University of Wisconsin; ROBERT J. TEMPELMAN, Department of Animal Science, Michigan State University; VALENCIA D. RILINGTON, Department of Animal Science, Michigan State University; ASHOK RAGAVENDRAN, Department of Animal Science, Michigan State University; NANCY E. RANEY, Department of Animal Science, Michigan State University; ANTONIO MARCOS RAMOS, Department of Animal Science, Michigan State University; FERNANDO FLORES CARDOSO, CPPSUL; DAVID B. EDWARDS, Department of Animal Science, Michigan State University; ERNST, C. W., Department of Animal Science, Michigan State University. |
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Título: |
Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
PLoS ONE, San Francisco, v. 6, n. 2, e16766, Feb. 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis provide novel candidate genes for important complex pig phenotypes. MenosBackground: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis... Mostrar Tudo |
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Thesagro: |
Genética; Suíno. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/33973/1/METAS-2011-FFC-Steibel-et-al-2011-PLoS-ONE-62-e16766.pdf
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Marc: |
LEADER 02341naa a2200265 a 4500
001 1888216
005 2011-08-04
008 2011 bl uuuu u00u1 u #d
100 1 $aSTEIBEL, J. P.
245 $aGenome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs.$h[electronic resource]
260 $c2011
520 $aBackground: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis provide novel candidate genes for important complex pig phenotypes.
650 $aGenética
650 $aSuíno
700 1 $aBATES, R. O.
700 1 $aROSA, G. J. M.
700 1 $aTEMPELMAN, R. J.
700 1 $aRILINGTON, V. D.
700 1 $aRAGAVENDRAN, A.
700 1 $aRANEY, NANCY E.
700 1 $aRAMOS, A. M.
700 1 $aCARDOSO, F. F.
700 1 $aEDWARDS, D. B.
700 1 $aERNST, C. W.
773 $tPLoS ONE, San Francisco$gv. 6, n. 2, e16766, Feb. 2011.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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| Registros recuperados : 10 | |
| 2. |  | CARDOSO, F. F.; STEIBEL, J. P.; ROSA, G. J. M.; ERNST, C. W.; BATES, R. O.; TEMPELMAN, R. J. Assessment of different selective phenotyping design strategies for genomics studies with outbred F2 populations. Journal of Animal Science, Savoy, v. 85, p. 373, 2007. Supplement 1.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 3. | | BIEGELMEYER, P.; OLIVEIRA, M. M.; CARDOSO, L. L.; GOMES, C. C. G.; HIGA, R. H.; DIONELLO, N. J. L.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F. Estimation of linkage disequilibrium, persistence of phase and effective population size of Brazilian Hereford and Braford breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver, British Columbia, Canada. Proceedings... Champaign: ASAS, 2014. Não paginado.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 4. | | BIEGELMEYER, P.; OLIVEIRA, M. M.; GOMES, C. C. G.; HIGA, R. H.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F. Linkage disequilibrium and persistence of phase in Hereford and Braford cattle. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. The integration of knowledge in animal production: abstracts. Campinas: SBZ, 2013. Não paginado. Resumo 6GYR.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 5. | | BIEGELMEYER, P.; OLIVEIRA, M. M.; GULIAS-GOMES, C. C.; HIGA, R. H.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F. Linkage disequilibrium and persistence of phase in Hereford and Braford cattle. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. The integration of knowledge in animal production: abstracts. Campinas: SBZ, 2013. Não paginado. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 6. | | BIEGELMEYER, P.; OLIVEIRA, M. M.; CARDOSO, L. L.; GOMES, C. C. G.; HIGA, R. H.; DIONELLO, N. J. L.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F. Estimation of linkage disequilibrium, persistence of phase and effective population size of Brazilian Hereford and Braford breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver, British Columbia, Canada. Proceedings... Champaign: ASAS, 2014. Não paginado.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 7. | | BIEGELMEYER, P.; OLIVEIRA, M. M.; CARDOSO, L. L.; GULIAS-GOMES, C. C.; HIGA, R. H.; DIONELLO, N. J. L.; CAETANO, A. R.; STEIBEL, J. P.; CARDOSO, F. F. Estimation of linkage disequilibrium, persistence of phase and effective population size of Brazilian Hereford and Braford breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver, British Columbia, Canada. Proceedings... Champaign: ASAS, 2014. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 8. | | ERNST, C. W.; STEIBEL, J. P.; ROSA, G. J. M.; TEMPELMAN, R. J.; BATES, R. O.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, N. E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B. Genome-wide expression QTL (eQYL) analysis of loin muscle tissue to identify candidate genes in pigs. In: ADSA CSAS ASAS JOINT ANNUAL MEETING, 2009, Montreal. Electronic abstracts... Champaign: ADSA: ASAS, 2009. LB4. Publicado em: Jornal of Animal Science, Champaign, v. 87, p. ii, 2009. Electronic Supplement 2.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 9. | | STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAM, A.; RANEY, N. E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. Genome-wide linkage analysis of gene expression of loin muscle tissue identifies candidate genes in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society of Animal Science, 2010. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 10. | | STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, NANCY E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. PLoS ONE, San Francisco, v. 6, n. 2, e16766, Feb. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| Registros recuperados : 10 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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